Author

S. Singer

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 3 Bioengineering· 1 Developmental Biology· 1 Evolutionary Biology· 1

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:DNA methylation· 3 Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Assay:metagenomics· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

Y. Chen· 3 shared B. A. Simmons· 2 shared C. J. Petzold· 2 shared J. Gladden· 2 shared P. D. Adams· 2 shared A. Arkin· 1 shared A. Banito· 1 shared A. Carles· 1 shared

Activity by Year

2016-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Y. Chen

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells

Chirag R. Parikh, Rachel A. Glenn, Yufang Shi, K. Chatterjee, Kritika Kasliwal, Emily Swanzey, S. Singer, S.C. Do, Yingqian Ada Zhan, Yasuhide Furuta, Mamta Tahiliani, Effie Apostolou, Alexandros Polyzos, Richard P. Koche, Jason G. Mezey, , Matthias Stadtfeld

The paper identifies genetic variants that influence DNA methylation stability and imprint deregulation in naive pluripotent stem cells across different mouse strains.

Stem Cell Reports · Mar 13, 2025Peer-reviewedDevelopmental Biology

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

J. Hofvander, A. Qiu, K. Lee, M. Bilenky, A. Carles, Q. Cao, M. Moksa, J. Steif, E. Su, A. Sotiriou, A. Goytain, L. Hill, S. Singer, I. Andulis, J. Wunder, , M. Hirst

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

bioRxiv · May 14, 2024 · PreprintCancer Biology

Simultaneous carbon catabolite repression governs sugar and aromatic co-utilization in Pseudomonas putida M2

S. Shrestha, D. Awasthi, Y. Chen, J. W. Gin, C. J. Petzold, P. D. Adams, B. A. Simmons, S. Singer

This study investigates carbon catabolite repression in Pseudomonas putida M2 during simultaneous sugar and aromatic co-utilization, revealing simultaneous repression by sugars and aromatics and the role of crc and small RNAs.

bioRxiv · May 23, 2023 · PreprintMicrobiology

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

J. Yan, Y. Chen, A. J. Patel, S. Warda, B. G. Nixon, E. W. P. Wong, M. A. Miranda-Roman, C. J. Lee, N. Yang, Y. Wang, J. Sher, E. Giff, F. Tang, E. Khurana, S. Singer, , P. Chi

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

bioRxiv · May 27, 2022 · PreprintCancer Biology

Genome-wide CRISPR and small-molecule screens uncover targetable dependencies in ATRT

D. J. Merk, S. Hirsch, F. Tsiami, B. Walter, L. A. Haeusser, S. Babaei, J. Admar, N. Casadei, C. Roggia, M. Spohn, J. Schittenhelm, S. Singer, U. Schueller, F. Piccioni, N. S. Persky, , G. Tabatabai

This study identifies targetable genetic dependencies in ATRT using CRISPR and small-molecule screens, revealing CDK4/6 inhibitors as potent therapeutic options.

bioRxiv · Dec 9, 2020 · PreprintCancer Biology

Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom

M. Y. Sachkova, M. Landau, J. M. Surm, J. Macrander, S. Singer, A. M. Reitzel, Y. Moran

The paper identifies a toxin-like neuropeptide in Nematostella vectensis that evolved from a neuropeptide gene into a venom component through duplication and functional specialization.

bioRxiv · May 28, 2020Evolutionary Biology

The response of Pseudomonas putida to a complex lignolysate

M.-R. Park, Y. Chen, M. G. Thompson, V. Benites, B. Fong, C. J. Petzold, E. E. K. Baidoo, J. Gladden, P. D. Adams, J. D. Keasling, B. A. Simmons, S. Singer

This paper shows that Pseudomonas putida can grow on lignolysate from sorghum, using aromatic monomers and other unknown factors like amino acids and ionic liquid.

bioRxiv · Sep 10, 2019 · PreprintMicrobiology

Rhodosporidium toruloides: A new platform organism for conversion of lignocellulose into terpene biofuels and bioproducts

J. Yaegashi, J. Kirby, M. Ito, J. Sun, T. Dutta, M. Mirsiaghi, E. Sundstrom, A. Rodriguez, E. Baidoo, D. Tanjore, T. Pray, K. Sale, S. Singh, J. Keasling, B. Simmons, , J. Gladden

This paper demonstrates that Rhodosporidium toruloides can efficiently convert lignocellulosic hydrolysates into terpenes like bisabolene and amorphadiene, outperforming purified substrates in productivity.

bioRxiv · Jun 23, 2017Bioengineering

Giardia alters commensal microbial diversity throughout the murine gut

N. R. Barash, J. G. Maloney, S. Singer, S. C. Dawson

This study investigates how Giardia infection affects microbial diversity in the murine gut, finding systemic dysbiosis with increased Proteobacteria and reduced Firmicutes and Melainabacteria.

bioRxiv · Nov 11, 2016Microbiology