Author

J. Seflova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

S. L. Robia· 5 shared L. M. Espinoza-Fonseca· 3 shared S. R. Cleary· 3 shared E. E. Cho· 2 shared X. Fang· 2 shared A. N. Smith· 1 shared A. V. Zima· 1 shared B. C. Knollmann· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersBiophysics

S. L. Robia

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Activation mechanism of the cardiac calcium pump by a small-molecule allosteric modulator

J. Seflova, C. Cruz-Cortes, G. Guerrero-Serna, S. L. Robia, L. M. Espinoza-Fonseca

This study uses TCSPC imaging to show that CDN1163, a SERCA2a activator, synergizes with ATP to shift SERCA2a toward a competent conformation, enhancing its function under physiological conditions.

bioRxiv · Sep 7, 2023 · PreprintBiophysics

Phospholamban Inhibits the Cardiac Calcium Pump Through Reversing the Allosteric Enhancement of Calcium Affinity by ATP

S. R. Cleary, J. Seflova, E. E. Cho, K. Bisht, H. Khandelia, L. M. Espinoza-Fonseca, S. L. Robia

This paper investigates how phospholamban (PLB) inhibits the cardiac calcium pump SERCA by reversing ATP-induced allosteric enhancement of calcium affinity, using biochemical assays and structural analysis.

bioRxiv · Jul 20, 2023 · PreprintBiochemistry

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

J. Seflova, J. A. Schwarz, A. N. Smith, B. Svensson, D. J. Blackwell, T. A. Phillips, R. Nikolaienko, E. Bovo, R. T. Rebbeck, A. V. Zima, D. D. Thomas, F. Van Petegem, B. C. Knollmann, J. N. Johnston, S. L. Robia, R. L. Cornea

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

bioRxiv · Jun 22, 2023 · PreprintBiophysics

STOICHIOMETRY OF THE SODIUM PUMP-PHOSPHOLEMMAN REGULATORY COMPLEX

J. Seflova, N. R. Habibi, J. Q. Yap, S. R. Cleary, X. Fang, P. M. Kekenes-Huskey, L. M. Espinoza-Fonseca, J. B. Bossuyt, S. L. Robia

The paper investigates the stoichiometry and structure of the NKA-PLM regulatory complex using fluorescence lifetime assays and simulations, revealing a (alpha-beta-PLM)2 composition.

bioRxiv · Oct 12, 2021 · PreprintBiophysics

Inhibitory and Stimulatory Micropeptides Preferentially Bind to Different Conformations of the Cardiac Calcium Pump

S. R. Cleary, X. Fang, E. E. Cho, M. P. Pribadi, J. Seflova, J. R. Beach, P. Kekenes-Huskey, S. L. Robia

The paper shows that inhibitory and stimulatory micropeptides bind to different conformations of the cardiac calcium pump SERCA, with their binding preference depending on intracellular Ca2+ levels.

bioRxiv · Jun 15, 2021Biophysics