B. Svensson

Kinetics and Mapping of Ca-driven Calmodulin conformations on Skeletal and Cardiac Muscle Ryanodine Receptors

The paper uses FRET to study CaM conformational changes on RyR in skeletal and cardiac muscle, finding CaM becomes more compact at high Ca2+ and showing isoform-specific differences.

Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State

This paper uses FRET to study how DPc10 and CaM interact with RyR2, revealing their distinct effects on channel function and structural changes.

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia

The paper develops an in vitro FRET assay to identify small molecule modulators of the L253P mutant β-III-spectrin actin-binding domain, identifying potential drug candidates for SCA5 treatment.

Two marine GH29 α-L-fucosidases from an uncultured Paraglaciecola sp. specifically hydrolyze fucosyl-N-acetylglucosamine regioisomers

The paper characterizes five GH29 fucosidases from a marine bacterium, showing that Fp231 and Fp284 specifically hydrolyze fucosyl-N-acetylglucosamine regioisomers.

Mechanistic basis for understanding the dual activities of the bifunctional Azotobacter vinelandii mannuronan C-5 epimerase and alginate lyase AlgE7

This study investigates the dual epimerase and lyase activities of AlgE7 from Azotobacter vinelandii, identifying key residues and conditions that regulate these functions.

Cardiac RyR N-terminal region biosensors for FRET-based high-throughput screening

This study develops FRET-based biosensors to screen for RyR modulators, identifying novel inhibitors and activators with therapeutic potential.

An 1,4-α-glucosyltransferase defines a new maltodextrin catabolism scheme in Lactobacillus acidophilus

This paper identifies a new maltodextrin catabolism pathway in Lactobacillus acidophilus involving an 1,4-α-glucosyltransferase and shows its conserved role in human gut lactobacilli.

Horse gluteus is a null-sarcolipin muscle with enhanced sarcoplasmic reticulum calcium transport

The paper analyzes Ca2+ regulation in horse gluteus muscle, finding high SLN RNA but low SLN protein, suggesting a non-coding role, and enhanced SR Ca2+ transport.

Phospholamban and sarcolipin share similar transmembrane zipper motifs that control self-association affinity and oligomer stoichiometry

This study identifies conserved transmembrane zipper motifs in phospholamban and sarcolipin that regulate their self-association and oligomer stoichiometry through hydrophobic interactions.

An NAD+-dependent sirtuin depropionylase and deacetylase (Sir2La) from the probiotic bacterium Lactobacillus acidophilus NCFM

This paper identifies and characterizes Sir2La, a NAD+-dependent sirtuin from Lactobacillus acidophilus NCFM, showing it deacetylates and depropionylates lysine residues.