Periodontitis promotes bacterial extracellular vesicle-induced neuroinflammation in the brain and trigeminal ganglion
J. Y. Ha, J. Seok, S.-J. Kim, H.-J. Jung, K.-Y. Ryu, M. Nakamura, I.-S. Jang, S.-H. Hong, Y. Lee, H.-J. Lee
This study shows that periodontitis promotes neuroinflammation via bacterial extracellular vesicles that cross the blood-brain barrier and activate TLR4/TLR8 signaling in the brain and trigeminal ganglion.
bioRxiv · Jul 9, 2023Pathology