H.-J. Lee

Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction

This study synthesizes and evaluates chalcone and pyrazoline derivatives as ELF3-MED23 PPI inhibitors, showing compound 10 effectively reduces HER2 levels and induces apoptosis in HER2-positive gastric cancer cells.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Periodontitis promotes bacterial extracellular vesicle-induced neuroinflammation in the brain and trigeminal ganglion

This study shows that periodontitis promotes neuroinflammation via bacterial extracellular vesicles that cross the blood-brain barrier and activate TLR4/TLR8 signaling in the brain and trigeminal ganglion.

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

Design of a holder for the improved maneuvering of the concurrent TMS-MRI setup

This paper introduces a TMS coil holder that enables quick adjustment of TMS coil position and orientation during concurrent TMS-MRI, improving workflow efficiency.

Baculoviral COVID-19 Delta DNA vaccine cross-protects against SARS-CoV2 variants in K18-ACE2 transgenic mice

This paper develops a baculoviral DNA vaccine targeting the SARS-CoV2 Delta variant, showing 100% survival against Delta and Omicron in mice, compared to 50% survival with the original vaccine.

Multi-omic Characterization of Pancreatic Cancer-Associated Macrophage Polarization Reveals Deregulated Metabolic Programs Driven by the GMCSF-PI3K Pathway

This study identifies metabolic markers and pathways in pancreatic tumor-associated macrophages using multi-omic analysis and in vitro models.

A redox cycle with complex II promotes sulfide quinone oxidoreductase dependent H2S oxidation

The paper identifies a redox cycle involving complex II and SQOR that sustains H2S oxidation when complex IV is inhibited, improving H2S clearance in cells exposed to microbiota-derived H2S.

Effects of Platycodon grandiflorum on Gut Microbiota and Immune System of Immunosuppressed Mouse

This study investigates the effects of Platycodon grandiflorum diets on gut microbiota and immune system in immunosuppressed mice, finding increased microbial abundance and immune-related biomarker changes.

Multi-omics approach to identify bacterial polyynes and unveil their antifungal mechanism against Candida albicans

This study identifies a bacterial polyyne resistance gene and elucidates its antifungal mechanism against Candida albicans using multi-omics approaches.

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

Pedigree-based measurement of the de novo mutation rate in the gray mouse lemur reveals a high mutation rate, few mutations in CpG sites, and a weak sex bias

The paper estimates the de novo mutation rate in gray mouse lemurs using linked-read sequencing and finds a high mutation rate, few mutations in CpG sites, and a weak sex bias.

Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated Immunopathology

This study identifies mitochondrial complex II disruption in intestinal epithelial cells as a key driver of T-cell mediated intestinal immunopathology across multiple disease models.

Differential risk of incident cancer in patients with heart failure: A nationwide population-based cohort study

This study finds that patients with heart failure have a higher risk of developing cancer compared to the general population, with increased risk observed across multiple cancer types.

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

This study shows macrophages in pancreatic cancer release pyrimidines that inhibit gemcitabine therapy by competing with the drug for uptake and metabolism, and reducing macrophage burden improves treatment response.

Pasakbumin A controls the growth of Mycobacterium tuberculosis by enhancing the autophagy and production of antibacterial mediators in mouse macrophages

This study shows pasakbumin A inhibits Mycobacterium tuberculosis growth in macrophages by enhancing autophagy and TNF-α production through ERK1/2 and NF-κB pathways.