Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Locally Altering Mechanical Properties of Cell Membranes
X. Guo, J. Steinkuhler, M. Marin, X. Li, W. Lu, R. Dimova, G. B. Melikyan
This study shows IFITM3 inhibits viral fusion by altering membrane curvature and stiffness, with its amphipathic helix playing a key role in these effects.
bioRxiv · Jun 25, 2020Biophysics