Nucleobase adduct-containing metabolites are MR1 ligands that stimulate self-reactive MR1T cells
A. Vacchini, A. Chancellor, Q. Yang, J. Spagnuolo, D. Joss, O. Oyas, A. Beshirova, C. De Gregorio, M. Pfeffer, J. Stelling, D. Häussinger, M. Lepore, L. Mori, G. De Libero
The paper identifies nucleobase adduct-containing metabolites as MR1 ligands that activate self-reactive MR1T cells, highlighting their role in detecting metabolic stress in cancer.
bioRxiv · Aug 26, 2022 · PreprintImmunology