M. Sugai

Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

In vitro activity of cefiderocol against carbapenemase-producing and meropenem-nonsusceptible gram-negative bacteria collected in the Japan Antimicrobial Resistant Bacterial Surveillance (JARBS-GNR)

This study evaluates the in vitro activity of cefiderocol against carbapenemase-producing and meropenem-nonsusceptible gram-negative bacteria from Japan, showing high susceptibility rates compared to other antibiotics.

Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan

This study analyzes genome sequences and antimicrobial resistance patterns of carbapenem-resistant Pseudomonas aeruginosa isolates from Japan, revealing genetic diversity and lower multidrug resistance prevalence compared to other regions.

Horizontal transmission of penicillin binding protein 1A caused a nationwide spread of β-lactam resistance in pneumococci

The paper traces the nationwide spread of β-lactam resistance in pneumococci through horizontal transmission of a specific PBP1A variant, highlighting its role in resistance emergence.

Isolation and characterization of bacteriophages against IMP-6-producing Klebsiella pneumoniae isolated from clinical settings in Japan

The paper isolates and characterizes 29 bacteriophages against IMP-6-producing Klebsiella pneumoniae from Japan, showing broad host ranges and demonstrating the effectiveness of a phage cocktail in delaying phage-resistant bacteria emergence.

Complete sequences of epidermin and nukacin encoding plasmids from oral-derived Staphylococcus epidermidis and their antibacterial activity

The paper reports the complete sequences of two plasmids from S. epidermidis that encode bacteriocins, showing partial differences from previously reported sequences and their antibacterial activity.

Prophage elements function as reservoir for antibiotic resistance and virulence genes in nosocomial pathogens

This study analyzes prophage elements in seven pathogens to show they carry a wide range of antibiotic resistance and virulence genes, with AMR genes being more conserved across species than VF genes.

Comparison of de-duplication methods used by WHO Global Antimicrobial Resistance Surveillance System (GLASS) and Japan Nosocomial Infections Surveillance (JANIS) in the surveillance of antimicrobial resistance

This study compares de-duplication methods from WHO GLASS and JANIS systems for AMR surveillance, finding small differences in patient counts and resistance percentages for E. coli.