Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
K. Strobl, J. Klufa, R. Jin, L. Artner-Gent, D. Krauss, P. Novoszel, J. Strobl, G. Stary, I. Vujic, J. Griss, M. Holcmann, M. Farlik, B. Homey, M. Sibilia, T. Bauer
This study shows that EGFR protects hair follicle stem cells from immune-mediated damage by maintaining JAK-STAT1-sensitive immune privilege, and its disruption leads to scarring hair loss, which can be reversed by JAK1/2 inhibition.
bioRxiv · Oct 11, 2023Immunology