M. Farlik

Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

This study shows that EGFR protects hair follicle stem cells from immune-mediated damage by maintaining JAK-STAT1-sensitive immune privilege, and its disruption leads to scarring hair loss, which can be reversed by JAK1/2 inhibition.

Dynamic control of gene expression by ISGF3 and IRF1 duringIFNbeta and IFNgamma signaling

The paper shows that IFN-I and IFN-gamma produce distinct transcriptomes over time due to different roles of ISGF3 and IRF1 in enhancer activation and chromatin accessibility.

Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation

This study uses single-cell RNA sequencing to compare indolent primary cutaneous B-cell lymphomas with other B-cell proliferations, finding they resemble persistent antigen reactions with germinal center features.

Cross-species analysis identifies conserved transcriptional mechanisms of neutrophil maturation

The paper identifies conserved transcriptional mechanisms of neutrophil maturation across zebrafish, mouse, and human by generating high-resolution transcriptional profiles and cross-species comparisons.

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations

The paper uses human embryonic stem cells to show that chromosomal gains in neuroblastoma impair neural crest development and enhance MYCN-driven tumourigenesis.

A distinct CD115- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice

The paper identifies a CD115- macrophage precursor in adult bone marrow that shares features with embryonic erythro-myeloid progenitors and is present at the maternal-embryonic interface.

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia

This study maps chromatin changes and single-cell immune profiles during ibrutinib treatment in CLL, identifying a shared regulatory program and patient-specific response dynamics.

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.