Machine learning analysis of the T cell receptor repertoire identifies sequence features that predict self-reactivity
J. Textor, F. Buytenhuijs, D. Rogers, E. Mallet Gauthier, S. Sultan, I. M. N. Wortel, K. Kalies, A. Fähnrich, R. Pagel, H. Melichar, J. Westermann, J. N. Mandl
The paper uses machine learning to identify TCR sequence features predicting self-reactivity, finding that n-nucleotide additions and acidic amino acids reduce self-reactivity.
bioRxiv · Nov 23, 2022Immunology