S. Klein

MXRA8 promotes adipose tissue whitening to drive obesity

This study identifies MXRA8 as a promoter of adipose tissue whitening that drives obesity, showing its role in reducing UCP1 expression and protecting against obesity in mice.

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

This paper identifies C95-C95 disulfide-bridge-mediated FGF2 dimerization as essential for membrane translocation and oligomer formation, while C77 is involved in Na,K-ATPase binding.

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice.

The paper shows that lower adipose lipin 1 in humans correlates with metabolic issues, and mice lacking adipocyte lipin 1 develop metabolic disorders.

Control of lipolysis by a population of oxytocinergic sympathetic neurons

This study identifies a population of oxytocinergic sympathetic neurons that regulate adipose tissue lipolysis and metabolic homeostasis in mice and humans.

Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling

The paper shows that liver injury suppresses systemic T cell immunity to viral infection, which can be reversed by inhibiting interferon and IL-10 signaling in preclinical models and human patients.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

Shared genetic architecture underlying root metaxylem phenotypes under drought stress in cereals

The paper identifies genes associated with root metaxylem phenotypes in maize and rice under drought and non-stress conditions using cross-species GWAS and gene co-expression networks.

Alternative splicing of SLAMF6 in human T cells creates a co-stimulatory isoform that counteracts the inhibitory effect of the full-length receptor

This study identifies an alternative splicing event in SLAMF6 that generates a co-stimulatory isoform, which enhances T cell cytotoxicity and is associated with improved anti-tumor responses in melanoma.

A collection of programs for one-dimensional Ising analysis of linear repeat proteins with point substitutions

The paper presents programs for analyzing the thermodynamics of linear repeat proteins using a 1D Ising model to study folding and mutation effects.

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

This study uses in situ cryo-electron tomography to visualize SARS-CoV-2 replication compartments and virion structure, revealing RNA filament organization and vRNP packaging mechanisms.

A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity

This study shows that inhibiting hepatic GABA production in obese mice reduces hyperinsulinemia, improves glucose tolerance, and decreases food intake, suggesting a role for hepatic GABA in obesity-related metabolic dysfunction.

Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release

This study identifies GABA as a novel hepatokine dysregulated in obesity, showing that hepatic GABA release affects serum insulin and insulin sensitivity.

Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies

The paper uses cryo-CLEM to study lamellar bodies in their unperturbed state, revealing their membrane architecture and a new outer membrane dome protein complex.

SLAMF6 deficiency augments tumor killing and skews towards an effector phenotype revealing it as a new T cell checkpoint

This study shows that SLAMF6 deficiency enhances T cell tumor-killing ability and shifts T cells toward an effector phenotype, suggesting SLAMF6 as a new immune checkpoint.

Deep Sequencing Reveals Transient Segregation of T Cell Repertoires in Splenic T Cell Zones During an Immune Response

The paper uses deep sequencing to show that T cell receptor repertoires in splenic T cell zones are transiently segregated during an immune response but not in the absence of antigen.