J. N. Mandl

The paper uses machine learning to identify TCR sequence features predicting self-reactivity, finding that n-nucleotide additions and acidic amino acids reduce self-reactivity.

The paper shows that TdT-mediated TCR diversity, characterized by lower-affinity T cells, aids in controlling chronic infections but not acute ones.

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

The paper shows that negative T cell selection on non-random peptides enables robust self-nonself discrimination despite incomplete silencing of self-reactive cells.