A polycomb-independent role of EZH2 in TGFβ1-damaged epithelium triggers a fibrotic cascade with mesenchymal cells
H. Q. Le, M. A. Hill, I. Kollak, W. Skronska-Wasek, V. Schroeder, J. Wirth, E. Schruf, K. Quast, F. E. Herrmann, M. J. Thomas, J. P. Garnett
The paper shows that EZH2, independent of Polycomb, drives fibrosis in TGFβ1-damaged epithelium by forming a new transcriptional complex with POL2 and nuclear actin.
bioRxiv · Jul 29, 2020Cell Biology