5'-S-(3-aminophenyl)-5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers
S. Zhang, H. Xue, N. K. Y. Wong, T. Doerksen, F. Ban, S. Anderson, S. Volik, Y.-Y. Lin, Z. Dai, I. Bratanovic, H. Cheng, C. C. Collins, A. Cherkasov, J. Wulff, Y. Wang
This paper identifies m-APTA, an MTA analogue that reduces NBA toxicity without hypothermia, improving safety for MTAP-deficient cancer treatment.
bioRxiv · Apr 17, 2024Cancer Biology