Pathogenicity, strain properties and interspecies transmission capacity of pure recombinant prion protein assemblies
H. Rezaei, D. Martin, L. Herzog, F. Reine, N. Aron, A. Igel, H. Klute, S. Youssafi, J.-B. Moog, P. Sibille, O. Andreoletti, J. Torrent, V. Beringue
This paper generates prions from recombinant prion protein assemblies with distinct biological properties and shows their transmissibility to mice, revealing structural features critical for prion pathobiology.
bioRxiv · Feb 27, 2023 · PreprintMicrobiology