D. Martin

Neutralisation sensitivity of the SARS-CoV-2 BA.2.87.1 variant

This study characterizes the neutralization sensitivity of the SARS-CoV-2 BA.2.87.1 variant and shows it is less resistant to antibodies than other variants, with a booster increasing neutralizing titers.

Undruggable oncoproteins cMyc and NMyc bind to mediator of transcription with superior high affinity

The paper identifies a conserved 9aaTAD region in c-Myc and N-Myc that binds the KIX domain with high affinity, suggesting a potential druggable target for MYC-driven tumors.

Transcriptomic signature and pro-osteoclastic secreted factors of abnormal bone marrow stromal cells in fibrous dysplasia

This study identifies a transcriptomic signature and secreted factors from Gs-activated BMSCs in fibrous dysplasia, linking them to pro-inflammatory and pro-osteoclastic behavior and potential therapeutic targets.

Towards the identification of the molecular toolkit involved in scale worm bioluminescence (Polinoidae, Annelida)

The paper identifies 16 candidate genes and 12 enriched GO terms potentially involved in bioluminescence in scale worms using RNA-seq and histological analyses.

Single tyrosine mutation in VE-cadherin modulates gene lung expressions: evidence for FOXF1 mediated S1PR1 upregulation to stabilize vessels in mice

This study shows that a single tyrosine mutation in VE-cadherin increases S1PR1 expression via FOXF1 binding, stabilizing lung vessels in mice.

Extended lifespan in female Drosophila melanogaster through late-life caloric restriction.

This study shows that late-life caloric restriction extends lifespan in female Drosophila melanogaster by reducing mortality and altering reproductive energy allocation.

Degradomic identification of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) as an ADAMTS9 and ADAMTS20 substrate

This study identifies ADAMTS9 and ADAMTS20 as substrates of MT1-MMP using N-terminomics, showing their role in regulating MT1-MMP activity and cell-surface function.

Late- life shift in caloric intake affects fly longevity and metabolism

This study shows that switching to a low-calorie diet late in life extends fly lifespan and reduces mortality, while switching to a high-calorie diet shortens lifespan and increases mortality.

The enigma of the SARS-CoV-2 microcirculation dysfunction: evidence for modified endothelial junctions.

This paper investigates how SARS-CoV-2 affects endothelial junctions by targeting VE-cadherin and ACE2, finding increased soluble fragments in severe COVID-19 patients.

Pathogenicity, strain properties and interspecies transmission capacity of pure recombinant prion protein assemblies

This paper generates prions from recombinant prion protein assemblies with distinct biological properties and shows their transmissibility to mice, revealing structural features critical for prion pathobiology.

African army ants at the forefront of virome surveillance in a remote tropical forest

This study uses army ants to sample the virome of a remote tropical forest, revealing a diverse array of viral sequences from multiple taxa.

Nuclei isolation protocol from diverse angiosperm species

This paper presents an optimized nuclei isolation protocol for diverse angiosperm species, yielding purified nuclei suitable for genomics experiments.

Variation in Human Herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals

The paper investigates the integration, excision, and transmission of HHV-6B in telomeres across tissues and individuals, revealing maternal transmission and dynamic transitions between integrated and free virus forms.

Solid state NMR reveals a parallel in register architecture for an infectious recombinant prion

The paper uses solid state NMR to analyze the structure of infectious recombinant prion, finding support for the parallel in register beta stack model over the 4-rung beta-solenoid model.

Assessing neuromodulation effects of theta burst stimulation to the prefrontal cortex using TMS-evoked potentials

This study assesses the neuromodulation effects of theta burst stimulation on the prefrontal cortex using TMS-evoked potentials in healthy participants, finding no significant effects but a moderate effect size for the N100 component.

Exploring the natural origins of SARS-CoV-2 in the light of recombination

This paper traces the origins of SARS-CoV-2 to horseshoe bats in China and Southeast Asia, identifies recombination events in Sarbecoviruses, and highlights the need for more wildlife sampling to understand zoonotic spillover risks.

Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites

This study shows fibrin regulates neutrophil effector functions at mucosal barriers, linking impaired fibrinolysis to oral mucosal disease.

Symptomatic fever management in children A systematic review of national and international guidelines

This study reviews fever management guidelines for children, finding inconsistent recommendations and low evidence levels for antipyresis thresholds.

The low-density lipoprotein receptor-related protein-1 is essential for Dengue virus infection

This paper identifies LRP1 as a new receptor for Dengue virus entry, showing it binds the viral envelope protein and inhibits infection, suggesting it as a potential drug target.

Extensive transfer of genes for edible seaweed digestion from marine to human gut bacteria

The paper shows gut bacteria have extensively adapted to digest seaweed polysaccharides through gene transfer from marine bacteria, revealing widespread metabolic plasticity in the human gut microbiome.

Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4

This paper develops a syngeneic mouse model of tobacco-associated HNSCC that shows high response rates to anti-CTLA-4 therapy.