Glucocorticoid rhythm disruption drives hyperinsulinaemia in mice through beta cell glucocorticoid receptor signalling
Jijo Wilson, Anna S Arzeno, Sanjeev Sharma, Agnieszka Agas, JACK LUNGSTRUM, Mary N. Teruel
This study shows that disrupting glucocorticoid rhythms in mice causes hyperinsulinaemia through beta cell GR signalling and reduced insulin clearance, highlighting insulin's role in maintaining glucose homeostasis.
bioRxiv · Sep 6, 2026 · PreprintPhysiology