Sanjeev Sharma

This study shows YAP/TAZ control ERK dynamics to balance progenitor expansion and differentiation by modulating PPARG activation thresholds and Hippo signaling.

This study shows that disrupting glucocorticoid rhythms in mice causes hyperinsulinaemia through beta cell GR signalling and reduced insulin clearance, highlighting insulin's role in maintaining glucose homeostasis.

This study uses metabolomics to analyze potato leaf metabolism during Alternaria solani infection, identifying key metabolic changes and defense markers.

The paper shows that inactivation of CDK4/6, CDK2, and ERK in G1-phase is necessary for irreversible cell cycle exit and differentiation commitment during terminal cell differentiation.

This study identifies PIP4K as a conserved enzyme in early metazoans that regulates growth and development through insulin receptor signaling.

This study compares the effects of high-fat diet and glucocorticoid-induced obesity on metabolic outcomes, finding that the latter prevents fatty liver despite similar adiposity.

This study uses a Drosophila nephrocyte model to show that OCRL loss causes endolysosomal defects and kidney dysfunction, which can be rescued by human OCRL but not by mutant variants.

This study shows that PIP4K regulates PIP3 levels and insulin sensitivity in Drosophila, affecting metabolism and development.