Author

Jack Toppen

Broad InstitutePrimary ORCID profile (0009-0007-7327-2604 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Jack ToppeniD4 papers · Broad Institute

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1 Assay:Hi-C· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Anders S. HanseniD· 1 shared Christoph ZechneriD· 1 shared Ilya M. FlyameriD· 1 shared James M. JusufiD· 1 shared Jin H. YangiD· 1 shared Leonid A. MirnyiD· 1 shared Luca GiorgettiiD· 1 shared Michele GabrieleiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Anders S. HansenORCID

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1 paper

Recent·Most cited

Genome-wide absolute quantification of chromatin looping

James M. Jusuf, Jin H. Yang, Jack Toppen, Simon Grosse‐Holz, Michele Gabriele, Pia Mach, Ilya M. Flyamer, Christoph Zechner, Luca Giorgetti, Leonid A. Mirny, Anders S. Hansen

This study calibrates Micro-C with live imaging to determine absolute chromatin looping probabilities in mouse cells, finding most loops occur at low frequencies.

Nature Structural & Molecular Biology · Jun 30, 2026Peer-reviewedBiophysics