James M. Jusuf

The paper shows that simple thresholding on 3D distance measurements from live-cell microscopy leads to inaccurate estimates of chromatin looping parameters, and proposes noise-aware methods for better accuracy.

This study calibrates Micro-C with live imaging to determine absolute chromatin looping probabilities in mouse cells, finding most loops occur at low frequencies.

This study uses live-cell imaging to show that enhancer-promoter interactions drive gene activation through transient contacts of ~25-42 nanometers.

The paper uses Region Capture Micro-C to study microcompartment formation during mitosis-to-G1 transition, finding they form in prometaphase and are influenced by chromatin compaction and loop extrusion.