Author

Jacob C. Garza

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 2

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Stephen J. HaggartyiD· 2 shared Alison GoateiD· 1 shared Celeste M M. KarchiD· 1 shared Cynthia CheniD· 1 shared Derian A. Pugh· 1 shared Geert PoelmansiD· 1 shared Gerard J.M. MartensiD· 1 shared Himanish BasuiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Stephen J. HaggartyORCID

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2 papers

Recent·Most cited

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

Kathryn R. Bowles, M. Catarina Silva, Kristen R. Whitney, Taylor B. Bertucci, Jacob C. Garza, Nathan C. Boles, Kevin H. Strang, Sidhartha K. Mahali, Jacob A. Marsh, Cynthia Chen, Derian A. Pugh, Yiyuan Liu, Joshua E. Berlind, Jesse D. Lai, Susan K. Goderie, , Sally Temple

This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.

bioRxiv · Feb 3, 2021 · PreprintNeuroscience

Disruption of The Psychiatric Risk Gene Ankyrin 3 Enhances Microtubule Dynamics Through GSK3/CRMP2 Signaling

Jacob C. Garza, Xiaoli Qi, Klaudio Gjeluci, Melanie P. Leussis, Himanish Basu, Surya A. Reis, Wen Ning Zhao, Nicolas H. Piguel, Peter Penzes, Stephen J. Haggarty, Gerard J.M. Martens, Geert Poelmans, Tracey L. Petryshen

This study shows that disrupting the ANK3 gene in mice affects microtubule dynamics via GSK3/CRMP2 signaling, linking it to psychiatric illness mechanisms.

Translational Psychiatry · Jul 25, 2018Peer-reviewedNeuroscience