Author
Icahn School of Medicine at Mount Sinai
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Chiara Pedicone, Sarah A. Weitzman, Joshua Orrick…·Masahiro Sonoshita
This study identifies anastrozole's off-target CYP4V2 as a neuroprotective factor in tauopathy models by reducing Tau phosphorylation and oxidative stress.
Kathryn R. Bowles, Derian A. Pugh, Yiyuan Liu…·Alison Goate
The paper identifies three H1 sub-haplotypes at the 17q21.31 locus associated with Parkinson's disease risk and links them to LRRC37A/2 expression in astrocytes.
Cheyenne D. Hurst, Derian A. Pugh, Measho H. Abreha…·Nicholas T. Seyfried
The paper identifies NRN1 as a mediator of cognitive resilience to Alzheimer's disease through integrative proteomic analysis and functional validation in neurons.
Kathryn R. Bowles, Derian A. Pugh, Laura‐Maria Oja…·Alison Goate
The paper identifies dysregulated coordination of MAPT exon 2 and exon 10 splicing in Alzheimer's and progressive supranuclear palsy, leading to distinct tau isoform accumulation.
Kathryn R. Bowles, M. Catarina Silva, Kristen R. Whitney…·Sally Temple
This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.