Author

Yiyuan Liu

Icahn School of Medicine at Mount SinaiORCID 0000-0002-9008-9170Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Alison GoateiD· 4 shared Anna Podlesny‐DrabiniokiD· 2 shared Edoardo M. MarcoraiD· 2 shared Abderhman AbuhashemiD· 1 shared Alexander PolyzosiD· 1 shared Andreas KloetgeniD· 1 shared Aristotelis TsirigosiD· 1 shared Bernice Porjesz AiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersNeuroscience

Alison GoateORCID

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5 papers

Recent·Most cited

ImmunologyCell ReportsPeer-reviewedJun 25, 2025

Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro

Anna Podlesny‐Drabiniok, Carmen Romero‐Molina, Tulsi Patel…·Alison Goate

This study reprograms human macrophages in vitro using cytokines to mimic Alzheimer's disease-relevant phenotypes, showing transcriptomic and functional changes similar to disease-associated microglia.

7 citations

humanbulk RNA-seq

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NeuroscienceJournal of NeurosciencePeer-reviewedFeb 13, 2024

Upregulated GIRK2 counteracts ethanol-induced changes in excitability and respiration in human neurons

Iya Prytkova, Yiyuan Liu, Michael B. Fernando…·Paul A. Slesinger

The paper investigates how upregulated GIRK2 affects ethanol-induced changes in human neurons, showing it counteracts excitability and respiration changes.

6 citations

humanelectronic health records

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NeurosciencebioRxivPreprintFeb 13, 2023

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer's disease and other disorders of lipid-rich tissues

Anna Podlesny‐Drabiniok, Gloriia Novikova, Yiyuan Liu…·Alison Goate

This study identifies BHLHE40/41 as key regulators of macrophage/microglia responses in Alzheimer's disease and other lipid-rich tissue disorders through sc/nRNA-seq analysis and functional validation.

6 citations

humanmouse

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NeurosciencebioRxivPreprintFeb 3, 2021

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

Kathryn R. Bowles, M. Catarina Silva, Kristen R. Whitney…·Sally Temple

This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.

1 citation

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintJun 7, 2019

KLF4 is involved in the organization and regulation of pluripotency-associated 3D enhancer networks

Dafne Campigli Di Giammartino, Andreas Kloetgen, Alexander Polyzos…·Effie Apostolou

This study investigates the role of KLF4 in chromatin reorganization and 3D enhancer rewiring during reprogramming of mouse embryonic fibroblasts to pluripotent stem cells.

4 citations

mouseChIP-seq

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