Jake Daane

Characterization of coordinated growth in macrodactyly caused by somatic mosaic activating mutations in PIK3CA

This study characterizes macrodactyly, a localized overgrowth disorder, by linking it to somatic mosaic PIK3CA mutations and demonstrating nerve and vascular regulation of growth through a novel animal model.

Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.

This study identifies celsr1a as essential for tissue homeostasis and aging onset in zebrafish, showing its role in maintaining progenitor cells and that caloric restriction can mitigate its effects.