Author

Jamie Guenthoer

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:benchmarking· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

Delphine DepierreuxiD· 3 shared Felicitas RuiziD· 3 shared Julie M. OverbaughiD· 3 shared Michelle LillyiD· 3 shared Vrasha Chohan· 3 shared Duncan RalphiD· 2 shared Helen Y. ChuiD· 2 shared Paul D. BieniasziD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Delphine DepierreuxORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Determinants of Natural Killer Cell-Mediated Antibody Dependent Cellular Cytotoxicity in SARS-CoV-2 Antibodies

Delphine Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie M. Overbaugh

This study identifies epitope targeting as the main determinant of ADCC activity in SARS-CoV-2 antibodies, showing that moderate binding and not SHM or neutralization potency drives immune cell activation.

PLoS Pathogens · Mar 12, 2026Peer-reviewedImmunology

Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains

Michelle Lilly, Felicitas Ruiz, William B. Foreman, Vrasha Chohan, Jamie Guenthoer, Delphine Depierreux, Viren A. Baharani, Duncan Ralph, Alex Harteloo, Helen Y. Chu, Paul D. Bieniasz, Tyler N. Starr, Julie M. Overbaugh

This study shows that re-infection with SARS-CoV-2 leads to broader and more potent antibodies against diverse sarbecovirus strains compared to antibodies from a prior infection.

mBio · Feb 25, 2026Peer-reviewedImmunology

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

Felicitas Ruiz, William B. Foreman, Michelle Lilly, Viren A. Baharani, Delphine Depierreux, Vrasha Chohan, Ashley L. Taylor, Jamie Guenthoer, Duncan Ralph, Frederick A. Matsen IV, Helen Y. Chu, Paul D. Bieniasz, Marceline Côté, Tyler N. Starr, Julie M. Overbaugh

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

PLoS Pathogens · Oct 28, 2024Peer-reviewedImmunology

BayesSpace enables the robust characterization of spatial gene expression architecture in tissue sections at increased resolution

Edward J. Zhao, Matthew R. Stone, Xing Ren, Jamie Guenthoer, Kimberly S. Smythe, Thomas Pulliam, Stephen R. Williams, Cedric R. Uytingco, Sarah E. B. Taylor, Paul Nghiem, Jason H. Bielas, Raphaël Gottardo

BayesSpace enhances spatial transcriptomics resolution and clustering, revealing tissue structures undetectable at lower resolutions.

Nature Biotechnology · Jun 3, 2021Peer-reviewedBioinformatics

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

Heidi Dvinge, Jamie Guenthoer, Peggy L. Porter, Robert K. Bradley

This study shows that spliceosome RNA components regulate tissue- and cancer-specific alternative splicing by modulating splice site choice and gene expression in breast cancer.

Genome Research · Oct 1, 2019Peer-reviewedGenomics