Helen Y. Chu

This study defines how mutations in RSV F protein affect antibody neutralization and shows that resistance to nirsevimab is rare but possible.

This study shows EBV reprograms B cells in COVID-19 patients, leading to autoimmune-like features such as autoantibodies and dysregulated lipid profiles, similar to lupus and multiple sclerosis.

The paper shows repeated SARS-CoV-2 vaccine boosters elicit variant-specific memory B cells and neutralizing antibodies, suggesting immune imprinting can be overcome with updated vaccines.

This study shows that re-infection with SARS-CoV-2 leads to broader and more potent antibodies against diverse sarbecovirus strains compared to antibodies from a prior infection.

This paper identifies spike mutations in recent SARS-CoV-2 variants that reduce neutralization by human antibodies and clinically relevant monoclonal antibodies, highlighting key sites and mechanisms affecting antigenicity and function.

This study compares CD4 T-cell cytokine responses to SARS-CoV-2 mRNA vaccines in infants and adults, finding restricted cytokine production in infants and differences by vaccine type.

This study compares neutralizing antibody specificities between recently infected infants and immune-imprinted adults, finding distinct targeting of SARS-CoV-2 spike domains.

APMAT analysis links CD8 T cell receptors, cognate antigens, and T cell phenotype/persistence using integrated experimental-computational methods.

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.

The paper maps how HA mutations affect neutralization by serum from different age groups, showing age-dependent antigenic effects and implications for viral evolution.

This study uses deep mutational scanning to assess how mutations in SARS-CoV-2 spike proteins affect ACE2 binding, cell entry, and serum escape, linking these effects to clade growth rates.

This study shows that immune imprinting from prior Wuhan-Hu-1 spike exposure persists after XBB.1.5 vaccine booster, with neutralizing antibodies dominated by pre-existing memory B cells.

SwabExpress is a simplified COVID-19 testing protocol that eliminates the need for transport media and nucleic acid extraction, achieving high sensitivity and specificity.

The paper predicts SARS-CoV-2 B-cell epitopes using computational methods and validates them with ELISA, finding two antigens with high sensitivity and specificity for serological diagnosis of COVID-19.