Julie M. Overbaugh

This study uses CRISPR-Cas9 to identify LY6E as an antiviral factor against coronaviruses in respiratory cells.

The paper identifies viral load-driven immune exhaustion as a factor enabling antibody breadth in HIV infection by analyzing longitudinal data from a Kenyan cohort.

This study identifies epitope targeting as the main determinant of ADCC activity in SARS-CoV-2 antibodies, showing that moderate binding and not SHM or neutralization potency drives immune cell activation.

This study shows that re-infection with SARS-CoV-2 leads to broader and more potent antibodies against diverse sarbecovirus strains compared to antibodies from a prior infection.

This study investigates the structural dynamics of mosaic SARS-CoV-2 spike trimers formed by co-assembling different variants, showing preserved stability and antigenicity with potential implications for polyvalent vaccine design.

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.