Author

Vrasha Chohan

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Julie M. OverbaughiD· 4 shared Delphine DepierreuxiD· 3 shared Felicitas RuiziD· 3 shared Jamie Guenthoer· 3 shared Michelle LillyiD· 3 shared Duncan RalphiD· 2 shared Helen Y. ChuiD· 2 shared Paul D. BieniasziD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

Julie M. OverbaughORCID

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Author profile →

4 papers

Recent·Most cited

Viral load-driven systemic immune exhaustion is an enabler of antibody breadth in HIV infection

Izumi de los Rios Kobara, Uma M. Mangalanathan, Soneida DeLine-Caballero, Kassandra Pinedo, Mikayla A. Stabile, Camilo A. Espinosa, Hannah L. Itell, Vrasha Chohan, Raymond Scott McClelland, Kishorchandra Mandaliya, Julie M. Overbaugh, Catherine A. Blish

The paper identifies viral load-driven immune exhaustion as a factor enabling antibody breadth in HIV infection by analyzing longitudinal data from a Kenyan cohort.

bioRxiv · Jun 17, 2026 · PreprintImmunology

Determinants of Natural Killer Cell-Mediated Antibody Dependent Cellular Cytotoxicity in SARS-CoV-2 Antibodies

Delphine Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie M. Overbaugh

This study identifies epitope targeting as the main determinant of ADCC activity in SARS-CoV-2 antibodies, showing that moderate binding and not SHM or neutralization potency drives immune cell activation.

PLoS Pathogens · Mar 12, 2026Peer-reviewedImmunology

Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains

Michelle Lilly, Felicitas Ruiz, William B. Foreman, Vrasha Chohan, Jamie Guenthoer, Delphine Depierreux, Viren A. Baharani, Duncan Ralph, Alex Harteloo, Helen Y. Chu, Paul D. Bieniasz, Tyler N. Starr, Julie M. Overbaugh

This study shows that re-infection with SARS-CoV-2 leads to broader and more potent antibodies against diverse sarbecovirus strains compared to antibodies from a prior infection.

mBio · Feb 25, 2026Peer-reviewedImmunology

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

Felicitas Ruiz, William B. Foreman, Michelle Lilly, Viren A. Baharani, Delphine Depierreux, Vrasha Chohan, Ashley L. Taylor, Jamie Guenthoer, Duncan Ralph, Frederick A. Matsen IV, Helen Y. Chu, Paul D. Bieniasz, Marceline Côté, Tyler N. Starr, Julie M. Overbaugh

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

PLoS Pathogens · Oct 28, 2024Peer-reviewedImmunology