Ontological Analysis of Brain Proteostasis Highlights the Sex-Dependent Trajectory of ApoE Isoform-Specific Regulation
Ariel E. A. Denos, Benjamin Jones, Noah G. Moran, Ethan Smith, Katie Brown, Noah E. Earls, Rebecca Burlette, Christian Garrard, ELISE CLARK, Esteban Coleman, Jared M. Elison, Jason Wells, Jossue Matute, Joshua Brown, Martin Sorensen, , John C Price
The paper uses proteomic analysis in ApoE knock-in mice to show sex-dependent differences in proteostasis regulation by ApoE isoforms, with ApoE4 showing early metabolic and mitochondrial changes.
bioRxiv · Jun 30, 2026 · PreprintBiochemistry