John C Price

The paper uses proteomic analysis in ApoE knock-in mice to show sex-dependent differences in proteostasis regulation by ApoE isoforms, with ApoE4 showing early metabolic and mitochondrial changes.

This study identifies poly-ubiquitin as a signal recruiting ATG9A to initiate basal autophagy by mediating autophagy foci assembly.

This study uses quantitative and kinetic proteomics to show that ApoE isoforms 2 and 4 alter mitochondrial protein regulation in the mouse brain compared to ApoE3, with distinct impacts on proteostasis.

The paper identifies key interactions in the enzymatic complex responsible for converting cysteine to thiazole in micrococcin biosynthesis, revealing a dynamic mechanism involving transient associations between scaffold and modifying enzymes.