BiochemistrybioRxivPreprint
Ontological Analysis of Brain Proteostasis Highlights the Sex-Dependent Trajectory of ApoE Isoform-Specific Regulation
Ariel E. A. Denos, Benjamin Jones, Noah G. Moran…·John C Price
The paper uses proteomic analysis in ApoE knock-in mice to show sex-dependent differences in proteostasis regulation by ApoE isoforms, with ApoE4 showing early metabolic and mitochondrial changes.
DOI 10.64898/2026.06.29.735293