Jennifer Gardner

Positional Interpretation of Cis-Regulatory Code and Nucleosome Organization with Deep Learning Models

This paper introduces PISA, a tool for interpreting sequence-to-function neural networks, enabling the discovery of nucleosome-positioning motifs and understanding cis-regulatory code through MNase-seq data.

Nascent protein retention at polysomes reduces kinetic barriers to self-assembly

The paper shows that increasing translation initiation rates accelerates nucleation of aggregating proteins at polysomes, suggesting cotranslational nucleation influences proteome evolution.