Cancer BiologybioRxiv
Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer
Jeff F Hiken, James I McDonald, Keith F Decker…·John R Edwards
The paper identifies epigenetic activation of PTGER4 as a mechanism promoting resistance to aromatase inhibitors in breast cancer and suggests it as a potential therapeutic target.
DOI 10.1038/onc.2016.397