FBXL21 regulates diurnal proteostasis and stress response by targeting DNAJB6 and client proteins
Ji Ye Lim, Jaebok Wi, Marvin Wirianto, Chorong Han, Sun Young Kim, Jane Nguyen, Sehyun Jung, Kristin L Eckel‐Mahan, Sung Yun Jung, Karyn Ann Esser, Zheng Chen, Seung Hee Yoo
This study identifies FBXL21 as a circadian E3 ligase that regulates proteostasis and stress response by targeting DNAJB6 and its client proteins, with implications for myopathies.
bioRxiv · May 22, 2026 · PreprintCell Biology