Y Wang

A highly Ca2+-permeable channelrhodopsin from the ancyromonad Nutomonas longa enables optogenetic control of Ca2+ signaling

This paper identifies NlCCR, a channelrhodopsin from Nutomonas longa, which enables precise optical control of Ca2+ signaling with improved properties compared to existing tools.

Cdc42 small GTPase is a novel regulator of the fibrogenic activation of human intestinal myofibroblasts

This study shows that Cdc42 regulates fibrogenic activation of human intestinal myofibroblasts by enhancing ECM production and contractile actomyosin cytoskeleton through AKT-mTOR signaling.

Coordinated immune-epithelial dynamics in the nasal epithelium protect against respiratory virus infection

The paper identifies IL13-driven immune-epithelial remodeling in the nasal epithelium that restricts respiratory virus infection by reshaping the mucus barrier.

Cryptochrome Loss Drives COPD-like Lung Pathology through Disrupted Alveolar Epithelial Proliferation and Immune Homeostasis

This study shows that loss of Cryptochrome 1 and 2 leads to COPD-like lung disease through disrupted epithelial proliferation and immune homeostasis, and that Nobiletin can alleviate these effects.

Three Muscle-Specific DAF-16/FOXO Transcriptional Targets Activated by Reduced Insulin/IGF-1 Signaling

The paper identifies three muscle-specific DAF-16/FOXO targets activated by reduced insulin/IGF-1 signaling in C. elegans through transcriptomic and chromatin analyses.

Re-evaluating the Need for Double Centrifugation in Plasma Cell-Free DNA Analysis

This study shows that single-spun plasma is sufficient for accurate cfDNA analysis, challenging the need for double centrifugation in liquid biopsy workflows.

SF3A2 deacetylation at lysin 10 mitigates myocardial pathological remodeling by reprogramming cardiomyocyte metabolism

This study shows that SF3A2 deacetylation at K10 reduces myocardial remodeling by altering cardiomyocyte metabolism, including glucose and fatty acid metabolism.

The Ins and Outs of Manganese: ZIP14 facilitates the efflux of excess manganese from the brain.

This study shows ZIP14 facilitates manganese efflux from the brain by relocalizing to the basolateral membrane in BBB endothelial cells, and its deletion causes Mn accumulation.

Enhanced methods for genetic assays in Drosophila cells

The paper introduces three improved variants of the VDA method for genetic assays in Drosophila cells, enhancing throughput and sensitivity for drug target identification.

An anatomical substrate of credit assignment in reinforcement learning

The paper shows how the basal ganglia solve the credit assignment problem through synaptic architecture and biophysical modeling in songbirds.