BioengineeringFrontiers in Bioengineering and BiotechnologyPeer-reviewed
Codon Deoptimization of Multispecific Biologics Reduces Mispairing During Transient Mammalian Protein Expression
Timothy Z. Chang, Weijun Ma, Jane Guo…·Dietmar Hoffmann
This study shows that deoptimizing serine codons in multispecific biologics reduces mispairing and increases protein purity during transient mammalian expression.
DOI 10.3389/fbioe.2026.1783067