Author

Jian Han

National University of Singapore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

Bryan Y.L. NgiD· 2 shared Haoqing SheniD· 2 shared Jesslyn ZhouiD· 2 shared Ka Wai Leong· 2 shared Larry NgiD· 2 shared Sze Jing TangiD· 2 shared Vanessa Hui En NgiD· 2 shared Vincent TanoiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Bryan Y.L. NgORCID

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2 papers

Recent·Most cited

Intron 13 retention expands the ADAR1 isoform repertoire to rewire PKR signaling and promote tumorigenesis

Bryan Y.L. Ng, Jesslyn Zhou, Sze Jing Tang, Yuhua Lim, Vincent Tano, Jovi Jian An Lim, Xi Ren, Ömer An, Jinghe Xie, Jian Han, Haoqing Shen, Larry Ng, Wei Liang Gan, Yangyang Song, Ka Wai Leong, , Peng Chen

The paper identifies novel ADAR1 isoforms generated by intron retention that sequester dsRNA to inhibit PKR and promote tumorigenesis in colorectal cancer.

bioRxiv · May 29, 2026 · PreprintCell Biology

Mitochondrial dsRNA: A Hidden Source of Immunogenic RNA in ADAR1 Deficiency

Haoqing Shen, Vincent Tano, Jian Han, Vanessa Hui En Ng, Wei Liang Gan, Sze Jing Tang, Ethan Tan, Shu Qin Peng, Larry Ng, Bryan Y.L. Ng, Ka Wai Leong, Xiaohui Sui, Jesslyn Zhou, Leilei Polly Chen

This study identifies mitochondrial dsRNA as a major endogenous dsRNA source in ADAR1 deficiency and proposes a mechanism linking ADAR1 dysfunction to immune activation.

bioRxiv · Jan 7, 2026 · PreprintCell Biology