Author

Leilei Polly Chen

National University of Singapore

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Cell Biology· 1

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Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

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Bryan Y.L. NgiD· 1 shared Ethan Tan· 1 shared Haoqing SheniD· 1 shared Jesslyn ZhouiD· 1 shared Jian Han· 1 shared Ka Wai Leong· 1 shared Larry NgiD· 1 shared Shu Qin Peng· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperCell Biology

Bryan Y.L. NgORCID

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintJan 7, 2026

Mitochondrial dsRNA: A Hidden Source of Immunogenic RNA in ADAR1 Deficiency

Haoqing Shen, Vincent Tano, Jian Han…·Leilei Polly Chen

This study identifies mitochondrial dsRNA as a major endogenous dsRNA source in ADAR1 deficiency and proposes a mechanism linking ADAR1 dysfunction to immune activation.

DOI 10.64898/2026.01.06.698045

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