Molecular BiologybioRxivPreprint
RIPK4 driven by TP53 mutations promotes resistance to redox stress of CRC by phosphorylating MTHFD1
Long Yu, Sha Zhou, Yanbo Xu…·Zhizhong Pan
This study identifies RIPK4 as a driver of chemotherapy resistance in CRC through TP53 mutations, enhancing MTHFD1 phosphorylation and NADPH production to reduce ROS and promote metastasis.
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