GP130 Y814 SIGNALING IS REQUIRED FOR THE DYNAMIN-MEDIATED ENDOCYTOSIS, MAPK/P38 ACTIVATION AND PERSISTENCE OF CHRONIC SYSTEMIC INFLAMMATION INDUCED BY HIGH FAT DIET
Jade Tassey, Y.-J. Lee, Jichen Yang, Siyoung Lee, Una Stevic, N. Liu, J. Lu, Andrew C. Drake, Vanessa Jabbour, Mary Vergel-Rodriguez, Ana Claudia Maretti-Mira, Lucy Golden‐Mason, Rong Lu, Denis A. Evseenko
This study shows that gp130-Y814 signaling is critical for dynamin-mediated endocytosis, MAPK/p38 activation, and chronic inflammation persistence in high-fat diet models.
bioRxiv · Feb 9, 2026 · PreprintCell Biology