N. Liu

GP130 Y814 SIGNALING IS REQUIRED FOR THE DYNAMIN-MEDIATED ENDOCYTOSIS, MAPK/P38 ACTIVATION AND PERSISTENCE OF CHRONIC SYSTEMIC INFLAMMATION INDUCED BY HIGH FAT DIET

This study shows that gp130-Y814 signaling is critical for dynamin-mediated endocytosis, MAPK/p38 activation, and chronic inflammation persistence in high-fat diet models.

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Have AI-Generated Texts from LLM Infiltrated the Realm of Scientific Writing? A Large-Scale Analysis of Preprint Platforms

This study analyzes AI-generated text infiltration in scientific preprints using LLM detectors, finding widespread use across domains and positive impacts on citation numbers.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Cell-cycle and Age-Related Modulations in Mouse Chromosome Stiffness

This study measures chromosome stiffness in mouse oocytes across cell cycle stages and age, finding increased stiffness in metaphase I oocytes and age-related stiffness changes.

Unbiased Complete Estimation of Chloroplast Number in Plant Cells Using Deep Learning Methods

This paper introduces a deep learning method for accurate 3D chloroplast counting in plant cells, achieving over 95% accuracy compared to manual methods.

Parallel Molecular Data Storage by Printing Epigenetic Bits on DNA

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Comparative analysis of methodologies for detecting extrachromosomal circular DNA

This study compares 7 analysis pipelines and 7 experimental methods for detecting extrachromosomal circular DNA, identifying the most effective approaches for short-read and long-read sequencing data.

Polygonum Cillinerve polysaccharide inhibits Transmissible gastroenteritis virus by regulating microRNA-181

This study shows that Polygonum Cillinerve polysaccharide inhibits TGEV infection by modulating miRNA-181 and reducing apoptosis in PK15 cells.

Extracting diamonds: Identifiability of 4-node cycles in level-1 phylogenetic networks under a pseudolikelihood coalescent model

The paper investigates the identifiability of hybrid nodes in 4-node cycles of phylogenetic networks using a pseudolikelihood coalescent model and provides sampling strategies to improve detection.

Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

This study introduces a next-generation immunocytokine, LH05, which shows improved antitumor effects in cold tumors with reduced toxicity compared to wild-type anti-PD-L1/IL-15.

Pontiella agarivorans sp. nov., a novel marine anaerobic bacterium capable of degrading macroalgal polysaccharides and fixing nitrogen

Myosin VIII and XI isoforms interact with Agrobacterium VirE2 protein and help direct transport from the plasma membrane to the perinuclear region during plant transformation

The paper identifies myosin VIII isoforms as facilitators of VirE2 plasma membrane tethering and myosin XI-K as essential for VirE2 cytoplasmic transport during Agrobacterium-mediated plant transformation.

Spatial transcriptomic atlas of shoot organogenesis in tomato callus

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

Sequential restoring O2 then unloading CO2 is beneficial against reperfusion injury: role of CO2 in metabolism

The paper shows that sequential reperfusion with high CO2 then normal CO2 reduces cardiac ischemic reperfusion injury in rat hearts by altering metabolic pathways.

Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment

This paper introduces a graphene biointerface for in vivo cardiac electrophysiology, demonstrating its use in sensing, stimulation, and treatment of arrhythmias.

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

Oncogenic metabolic rewiring independent of proliferative control in human mammary epithelial cells

The paper compares metabolic flux in cancerous and normal human mammary epithelial cells using 13C-tracing and MFA, finding distinct metabolic pathways activated in cancer cells.

A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

This study develops a mosaic-type trimeric RBD vaccine that induces strong neutralizing antibodies against Omicron and other SARS-CoV-2 variants in rats.

A novel anti-PD-L1/IL-15 immunocytokine overcomes resistance to PD-L1 blockade and elicits potent antitumor immunity

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

Waning immune responses against SARS-CoV-2 among vaccinees in Hong Kong

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

Long Noncoding RNA RROL Provides Chromatin Scaffold for MYC-WDR82 Interaction to Impact Lipid Metabolism and Tumor Cell Growth in Multiple Myeloma

This study identifies RROL as a therapeutically actionable lncRNA in multiple myeloma that supports tumor growth through chromatin scaffolding of MYC-WDR82 interaction.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.