Jie Yu

Structural basis of GABA transport by the vesicular inhibitory amino acid transporter VIAAT

This study determines the cryo-EM structures of human VIAAT in different states to elucidate its mechanism of GABA transport and how mutations affect inhibitory neurotransmission.

PGG Enhances Olaparib Efficacy via cGAS-STING Signaling and Sensitizes Triple-Negative Breast Cancer to PD- L1 Blockade

This study shows PGG enhances olaparib efficacy in TNBC by inducing HRD and activates cGAS-STING to sensitize tumors to PD-L1 blockade, converting 'cold' to 'hot' tumors.

Multi-omic landscape of Mn(II) oxidation in Achromobacter pulmonis ss21: From multicopper oxidase to metabolic support electron transfer

This study identifies the molecular mechanisms of Mn(II) oxidation in Achromobacter pulmonis ss21, showing high efficiency and highlighting its potential for bioremediation.

SurfDock is a Surface-Informed Diffusion Generative Model for Reliable and Accurate Protein-ligand Complex Prediction

SurfDock improves protein-ligand complex prediction by integrating multiple protein representations into a diffusion model, achieving higher accuracy and physical plausibility than existing methods.

Autonomous Shaping of the piRNA Sequence Repertoire by Competition between Adjacent Ping-Pong Sites

The paper compares piRNA sequence repertoires in two silkworm cell lines and finds that repertoire changeability negatively correlates with piRNA biogenesis efficiency due to competition between adjacent ping-pong sites.

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent manner

This study identifies Exo70's role in herpesvirus secretory vesicle tethering and virion release via the exocyst complex, showing ES2 inhibits herpesvirus infection.