Lin Wang

Metabolite-centric Knowledge Graph Unveils Predictive and Mechanistic Insights through Self-supervised Multimodal Learning

This paper introduces MetaKG, a metabolite-centric knowledge graph with self-supervised learning that improves representation learning and uncovers biochemical relationships.

Deciphering the gene-centric spatial dynamics across tissue and time with GeneSPOT

GeneSPOT is a gene-centric framework that characterizes spatial gene relationships and their reorganization across biological conditions and time.

Mapping First In Vivo Ebolavirus Infection Events

This study uses EBOV trVLPs to map first in vivo infection events in mice, showing direct infection of T cells, monocytes, dendritic cells, and Langerhans cells.

β-Glucan Modulates Monocyte Plasticity and Differentiation Capacity to Mitigate DSS-Induced Colitis

This study shows that β-glucan reprograms monocytes to reduce DSS-induced colitis severity by enhancing reparative macrophage generation and epithelial regeneration.

Stromal asparagine supports tumor adaptation to oxidative phosphorylation inhibition through SLC38A4-mediated metabolic coupling

This study identifies asparagine (ASN) as a critical metabolite supplied by cancer-associated fibroblasts (CAFs) to pancreatic ductal adenocarcinoma (PDAC) cells under oxidative phosphorylation (OXPHOS) inhibition, revealing SLC38A4 as a mediator of metabolic coupling that supports tumor adaptation.

Integrated single-cell and spatial transcriptomic analysis of T cell exhaustion and immunometabolic remodeling in HPV-positive oropharyngeal squamous cell carcinoma

This study integrates single-cell and spatial transcriptomics to uncover mechanisms of immune checkpoint resistance in HPV-positive oropharyngeal cancer, identifying a KMT2D-KLF7-PD-L1 axis as a therapeutic target.

Sex-determination cascade orchestrates male-male pheromone synthesis in the bean bug

The paper identifies two male-male pheromones in bean bugs and shows their synthesis is controlled by the sex-determination cascade Rpfmd-Rpdsx.

Stabilizing mammalian RNA thermometer confers neuroprotection in subarachnoid hemorrhage

This paper identifies RNA G-quadruplexes as temperature and potassium sensors that regulate alternative splicing and neuroprotection in subarachnoid hemorrhage.

Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila

This study uses LbNOX in Drosophila to show tissue-specific effects of NADH/NAD+ modulation on aging, revealing that targeting non-neuronal tissues can rejuvenate sleep in aged flies.

cfGWAS reveal genetic basis of cell-free DNA features

This study conducts the first GWAS on cell-free DNA (cfDNA) features in pregnant women, identifying 84 genetic loci and revealing causal relationships between hematological indicators and cfDNA biology.

Effect of Over-expression of GRXs on Thermo and Acetic Acid Stress Tolerance of Saccharomyces cerevisiae

This study shows over-expressing GRX genes improves Saccharomyces cerevisiae growth under thermal and acetic acid stress, enhancing ethanol production potential.

An ultrasensitive method for detecting mutations from short and rare cell-free DNA

This paper introduces OPERA, a method for detecting low-frequency mutations in short and rare cell-free DNA, achieving higher sensitivity than existing methods.

Activation of IP10/CXCR3 signaling with highly coincidental with PrPSc deposit in the brains of scrapie infected mice

The paper shows IP10/CXCR3 signaling is activated in prion-infected mice brains, coinciding with PrPSc deposits, suggesting it as a potential therapeutic target.

DNA damage alters nuclear mechanics through chromatin reorganisation.

This study investigates how DNA damage affects nuclear mechanics through chromatin reorganisation, finding reduced nuclear stiffness and increased chromatin decondensation that may enhance DNA repair.

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

The paper introduces a new sequencing chemistry (CoolMPS) that improves signal intensity and eliminates scar interference in massively parallel sequencing.

Advanced Whole Genome Sequencing Using an Entirely PCR-free Massively Parallel Sequencing Workflow

This paper demonstrates that PCR-free whole genome sequencing using the DNBSEQ platform and machine learning variant calling significantly reduces InDel errors and improves variant calling performance.

Reliable Multiplex Sequencing with Rare Index Mis-Assignment on DNB-Based NGS Platform

The paper evaluates index mis-assignment rates on DNB-based sequencing platforms and finds they are exceptionally low, suggesting reliable multiplex sequencing.

3’ Branch Ligation: A Novel Method to Ligate Non-Complementary DNA to Recessed or Internal 3’OH Ends in DNA or RNA

The paper introduces a novel ligation method called 3BL that allows non-complementary DNA to be ligated to 3' ends of DNA or RNA, improving NGS library construction by reducing adapter dimer issues and increasing yield.

The Effectiveness of China’s National Forest Protection Program and National-level Nature Reserves, 2000 to 2010: PREPRINT

This study evaluates China's National Forest Protection Program and National-level Nature Reserves from 2000 to 2010, finding reduced deforestation rates within protected areas despite overall losses.

Spatial epidemiology of networked metapopulation: An overview

This paper reviews spatial metapopulation dynamics to model and evaluate disease intervention strategies for emerging infectious diseases.