Molecular BiologybioRxivPreprint
A K27-linked Ubiquitin Checkpoint Controls NOTCH Homeostasis
Behzad Mansoori, Ying Song, Tian Zhang…·Chengyu Liang
This study identifies UVRAG as a negative regulator of NOTCH1 by promoting K27-linked ubiquitination and lysosomal degradation, revealing a checkpoint to prevent excessive NOTCH signaling.
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