BiochemistryeLifePeer-reviewed
AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone
Assmaa ElSheikh, Camden M. Driggers, Ha H. Truong…·Show‐Ling Shyng
The paper identifies a novel KATP channel pharmacochaperone, Aekatperone, using AI screening and cryoEM, showing reversible inhibition and functional recovery of trafficking mutants.
DOI 10.7554/elife.103159.3