Biophysics-based protein language models for protein engineering
Sam Gelman, Bryce Johnson, Chase R. Freschlin, Arnav Sharma, Sameer D’Costa, John Peters, Anthony Gitter, Philip A. Romero
This paper introduces METL, a protein language model that integrates biophysical modeling with machine learning to predict protein properties and design functional variants.
Nature Methods · Sep 1, 2025Peer-reviewedBioinformatics