Molecular BiologybioRxivPreprint
S-Phase induced RNAs control ORC1 engagement to H2A.Z and firing of early DNA replication origins.
Simone Ummarino, Larysa Poluben, Alexander K. Ebralidze…·Annalisa Di Ruscio
The paper identifies S-phase RNAs that anchor ORC1 to H2A.Z, enabling DNA replication initiation and revealing an RNA-mediated mechanism for replication origin formation.
DOI 10.1101/2021.10.19.465050