Author

Jonathan Tart

AstraZeneca (United Kingdom)

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Molecular Biology· 1

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Approach:statistical model· 1

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Gustavo J. Gutierrez· 1 shared Jonathon DeBonisiD· 1 shared Joseph QuinlaniD· 1 shared Junmin Wang· 1 shared Maxime CouturieriD· 1 shared Meizhong JiniD· 1 shared Oleg A. IgoshiniD· 1 shared Ryan RichardsiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperMolecular Biology

Gustavo J. Gutierrez

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1 paper

Recent·Most cited

Molecular BiologyJournal of Chemical Information and ModelingPeer-reviewedApr 13, 2026

Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design

Seok Joo Chae, Jonathon DeBonis, Joseph Quinlan…·Oleg A. Igoshin

This paper develops a mathematical framework to analyze molecular glues, showing that strong ternary complex binding affinity is key for performance, with degrader performance limited by catalytic efficiency and target half-life.

1 citation

statistical model

𝕏 PostBluesky