MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewed
Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay
Esteban Carlos Serra, Luis Tavernelli, Imanol Peña…·Raquel Gabarro
The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.